If you are looking for unique ruby rings, there are basically two ways to find them. You can look for a unique setting, or a unique stone (or, combine both if you want something extra special).
Finding a special stone is perhaps more difficult. You will probably want to look for real ruby rings that use natural stones and may have a color cast or inclusion that make them unique, but be prepared to pay a premium for a mined natural ruby.
All rubies are “real.” Man-made rubies are now called “lab created” rather than “synthetic.” The term synthetic implies made out of a different material or by a different process. But, lab-created rubies have the same chemical composition and crystal structure as a natural ruby, except they are created in a laboratory rather than found in nature.
Rubies are aluminum oxide that has been heated to form crystals. The characteristic color comes from metallic impurities in the matrix. Crystals that are not ruby-colored are called sapphires, and come in many different colors.
Natural rubies are found in many places, but most are mined in Myanmar; the southeast Asian country formerly called Burma. Myanmar is politically unstable, so the prices of rubies are volatile.
Both natural and lab-created rubies are irregular in shape and must be cut to make jewelry. Over the centuries, the shapes to reflect light best from various gemstones have been refined so that a unique cut may produce the result you want.
Finding a unique setting is easier with On-line stores having large selections of different settings from which you can choose. Or, for a truly unique ring, you can have a setting custom made specially for your needs. Jewelry artists can carve a one-of-a-kind ring from wax and cast it in gold. If you pick a natural stone, it makes sense to show it off with a special ring made just for you.